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Cell Cycle Regulation | Basic Overview

The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subsequently the partitioning of its cytoplasm and other components into two daughter cells in a process called cell division. In cells with nuclei (eukaryotes), (i.e., animal, plant, fungal, and protist cells), the cell cycle is […]

Cyclins and CDKs Cell Cycle Regulation

Shortcut Guy Regulation

A cell can switch from G0, or cell cycle arrest, to G1 once cells have attained a critical size. For multicellular organisms, growth factors and mitogens, which are substances encouraging cell division, need to be present. For unicellular organisms, nutrients must be adequate in surroundings. Once G1 is initiated, Cyclin D is synthesized and drives the G1/S phase transition. In eukaryotes, Cyclin D binds with CDK 4 and CDK 6. These two complexes can partially phosphorylate retinoblastoma […]

34 comments CDKs, cell cycle, control, Cyclins, kinase, p27, p53